Go to nanoparticles.org Home Page Small Particle Formation -
An Introductory Survey

Surface Modification Chemistries for
Particles and Interfaces

Small Particle Formation - An Introductory Survey

11 March 2016, Friday, 8:30am - 5pm

Surface Modification Chemistries for Particles and Interfaces

12 March 2016, Saturday, 8:30am - 5pm


Holiday Inn Express San Diego Downtown, Cypress Room
1430 Seventh Avenue San Diego, CA 92101, USA
tel: 1-619-696-0911
Course participants qualify for a favorable $239+tax room rate if booked by 26 February 2016. Contact Melanie (see registration form) for booking code.

Small Particle Formation - An Introductory Survey
Friday, 11 March 2016


This introductory survey course is targeted at the advanced undergraduate and beginning graduate student level and will be useful to R&D chemists, materials scientists and engineers, and innovators in developing approaches to synthesizing various types of particles for diverse applications and materials. It is presumed that students have familiarity with a first course in organic chemistry.

An overview of physical factors presenting barriers to stabilizing nanoparticles is presented and the approaches available to overcoming these challenges are articulated. This course illustrates the chemistries and procedures for preparing nanoparticles through microparticles, 2 nm to 300 um in diameter, of organic and inorganic phases. The course focuses on reviewing all of the practical methods currently used in diverse industrial and laboratory processes from high-volume production to bench-scale. Applications are illustrated in diverse technologies including assays and diagnostics and pharmaceuticals, ceramics, chemical mechanical polishing, coatings, cosmetics, dispersions, drug delivery, displays, imaging systems, inks and printing, pigments, marking, and separations.

Registration Form

Topics Covered:

Course Overview
  Course Outline, Surface Energetics, Solubility, Nucleation, Ostwald Ripening, Stabilization, Matrix Stabilization, Compartmentalization

Emulsions, Microemulsions
  Emulsification, Homogenization, Formulation, Limited Coalescence, Low Shear Processing, Microemulsions, Miniemulsions, Hydrophobic Additives, Foams and Aerosols

  Pharmaceutical Applications, Inorganic Salts, Ceramic Precursors, Vacuum Vaporization, Plasmas, Combustion, Spray Drying, Supercritical Fluid Technology

  Types of Milling, Dry Grinding, Wet Milling, Particle Fracture, Deagglomeration, Media Size Effects, Mechanicochemical Processing

  Problems Encountered, Morphology Control, Single and Double Jet, Organic Extraction, Liquid Membranes, Thermodynamic versus Kinetic Control

Organic Precipitation
  Dispersions from Emulsions, Mixed Micellization, Solvent Shifting, pH Shifting, Supercritical Fluid Methods

Inorganic Precipitation
  Inorganic Salts, Oxides, Metals, Semiconductors, Quantum Dots, Pigments, pH and Solvent Shifting, Sol-Gel Condensation, Solvothermal Condensation, Mechanicochemical Activation

  Classifications, Radical Polymerization, Emulsion Polymerization, Dispersion Polymerization, Suspension Polymerization, Miniemulsion Polymerization, Limited Coalescence, Inverse Emulsion Polymerization, Microemulsion Polymerization, Solution Polymerization

  Latex Particles, Carbon Microspheres, LbL Coating, Inorganic Composites

  Motivation, Applications, Morphologies, Double Emulsions, Polymeric Coating, Coacervate/Phase Separation, Liquid Coating, Shell Polymerization


Surface Modification Chemistries for Particles and Interfaces
Saturday, 12 March 2016


The science and technology of nearly all particle-based materials, drug delivery systems, diagnostic methods, controlled release systems, composites, etc., involve on every length scale, from the molecular to the macro, surface and interfacial phenomena that can be tuned by varying the surface and interfacial energy and by varying the specific chemical interactions and chemical groups populating such surfaces and interfaces. This is particularly true in formulating multiphase fluids for coatings, and in making pigments and other particulate additives stable in coating fluids, prepolymers and resins of a particular coated layer or composite film. Being able to take a particle and make it “happy” in a dispersion environment that otherwise would be unstable and lead to coating defects and untoward dispersion destabilization is a skill that will make the student more competitive in the broad advanced materials and pharmaceutical industries. This course augments introductory organic, inorganic, and colloid chemistry courses by providing a broad range of practical applications of physical and synthetic chemistries that enable the student to achieve many different kinds of surface and interfacial modifications.

Basic physical-chemical methods, basic organic and inorganic coupling chemistries, and living polymerization methods are reviewed and applied to achieving diverse forms of surface and interfacial modification suitable for nanoparticles through high volume and high surface area planar substrates. The emphasis is on the application of various chemistries to enable highly value-added materials to be made in a chemically stable and robust manner.

The course is targeted at the advanced undergraduate and beginning graduate student level and will be useful to R&D chemists, materials scientists and engineers, and innovators in developing a toolbox of methods to use in optimizing formulations for advanced materials and applications.

This course reviews and illustrates the practical applications of physical, organic, and inorganic chemistry, as learned in undergraduate courses, and presents methods, for the constructive chemical surface modification of particulate and planar substrates used in diverse applications in the coatings, materials, and pharmaceutical industries. The course focuses on physical methods such as layer-by-layer assembly, physical adsorption, and upon diverse chemistries including thiol-driven self-assembly on particular substrates, diverse coupling chemistries, sol-gel silane-based chemistries, living polymerization methods, grafting chemistries including click chemistry, surface-initiated polymerization, encapsulation chemistries, and applications in controlled release, formulating composites, and advanced applications in diagnostics and array technologies.

A comprehensive reading list and extensive references are provided to facilitate the practical review of the topics covered as the need for detail arises in the workplace and development laboratory.

Registration Form

Topics Covered:

Course Overview
  Why modify surfaces? What is surface modification? How can we modify surfaces? Surface Energetics, Physical Methods, Chemical Methods, Surface Reconstruction, Coupling Chemistries, HighEnergy Treatments, Wet Chemical Treatments, Grafting, Targeting, Diagnostics

High Energy Treatment
  Plasma, UV, Sputtering, CVD, Fluidized Bed Coating, Surface Functionalization, Wet Chemical Treatment, Biomaterials, Composites, Aerosol-Assisted Particle Coating

Layer-by-Layer Assembly
  LbL Methods, Suitable Polymers, Synthetic Nacre, Covalent LbL, LbL with Diverse NanoObjects

Coupling Chemistries
  Arene Radical Cations, Hydroxyl Functions, Amine Functions, Thiol Reactive Groups, Carboxyl Functions, Coupling Agents, Click Chemistries, PEG Surfaces

Silane Coupling
  Sol-Gel Chemistry, Silane Coupling Agents, Hydrosilation, UV Curable Nanocomposites, Supramolecular Ionic Liquids

ATRP and Related Living Polymer Polymerization
  ATRP, Reverse ATRP, Applications, Surface Initiated Polymerization, Nitroxyl-Mediated LFRP, RAFT Polymerization, ATRP in Air

Anionic and Cationic Living Polymer Polymerization
  LASIP on Silica, Brushes by LASIP, Anionic Polymerization in Clays

Physical Adsorption
  Effects on Dispersion Stability, Adsorption Analyses, Specific Surface Area Effects, Experimental Methods, Ion Adsorption, Polymer Adsorption

Grafting Chemistries
  Surface Initiated Polymerization, Brush Packing, Graft Radical Polymerization, Photografting, Grafting Free Chains within Preexisting Brushes

Encapsulation and Controlled Release
  Motivation, Phase Change Encapsulation, Encapsulation by Polymer Adsorption, Encapsulation by Polymerization, Encapsulation by Solvent Extraction, Emulsification Methods, Encapsulation by LbL

Advanced Printing and Diagnostics
  A Burgeoning New Industry, Gene Analysis by Arrays, Microcontact Printing, Hyperbranched Polymers, Patterned Adsorption, Affinity Contact Printing, Microcontact Printing, Functional Antibody Arrays, Protein Immobilization



The basic course fee of $1095 (or discounted amount; see Registration Form) includes a book of slides in electronic form on a USB stick for each course subscribed, luncheon, and coffee breaks mid-morning and mid-afternoon. Discounts for taking both course and for full-time students are also available (see Registration Form).

Registration Form


The course venue is the Cypress Room at the Holiday Inn Express San Diego Downtown [1430 Seventh Avenue, San Diego,CA, USA]. This site is on the periphery of the Gaslamp Quarter proximal to the Convention Center.

Directions & Map

© 2016 Particles Conference
tel 1-585-413-8264; fax 1-585-482-7795