The formation of solid-dispersed particle systems as fine as 10 nanometers via comminution is a multi-discipline technology that can create or extend functionality to a broad range of materials. Learn that “it pays to think small” and develop an understanding for this commercializable technology. Size reduction technology is applicable in many unrelated areas including pharmaceuticals, biotechnology, microbiology, diagnostic agents, and other advanced solid materials. This course will provide the attendee with an understanding of the characteristics, opportunities and benefits of ultrafine solid particle dispersed systems using comminution size reduction dispersion technology.
Who Should Attend:
R&D managers , engineers, scientists and bio-technologists interested in the value-added consequences and benefits of forming ultrafine particle-based systems of functional materials are encouraged to attend. The course is primarily targetted at the B.S. level, but graduate and postgradaute level students seeking a very introductory overview of this processing technology will also greatly benefit from the course.
Topics Covered:
Introduction
Ground rules
Interactive (Q&A encouraged and welcome)
Overview of schedule, presentation, breaks, discussion
Technology and miniaturization- think tinyWhat is Fine Particle Technology ???
Vision (Richard Smalley)
Why miniaturization-faster/smaller/cheaper
Particle Building Blocks (diagram)
Dispersions and coatings
High surface area materials
Consolidated materials and parts
Formation of Solid Particles - comminution technologyApplications for this technology
Types of dispersed systems (solid/gas, solid/liquid, solid/solid)
Conventional Size Reduction Capabilities (sub-micron systems) and Bead milling technology
Micro-milling and capabilities (nanoparticle formation)
Pharmaceuticals, Implant Technology,Characteristics of sub-micron and nanoparticle solid-dispersed systems
Microbiology, Cosmeceuticals, Neutriceuticals, others (Information storage, inks, electronics mineral processing, office products, agricultural products)
Established technology, Excellent dispersion stabilityComparison of sub-micron and nanoparticle systems:
Property amplification, Reliable analytical methods
Comparison of size reduction methods
Processing speed and output, Dispersion purity
Cost, Process scalability, Skill level, Process flexibility
Solids content, Capital expense, Extent of size reduction
Size, surface area, number of particle per unit weightWhat are limits of size-reduction and bead milling technology?
Purity, Micrographs
Size, surface area expectations (10 X better than sub-micron)What are characteristics of fine particles that make for commercial utility?
Solubility amplification, Surface area sensitive propertiesHow compelling are potential applications for – ultrafine particles and size reduction technology?
Incorporation technology for high value materials
Incorporation of insoluble materials
Elimination of hazardous organic solvents
Physics of light scattering (more spectrally selective pigments)
Where are opportunities for ultrafine solid systems and size reduction technology ?
Drug Delivery, Neutriceuticals, Cosmeceuticals,Commercial benefits of ultrafine particle systems:
Advanced materials, Diagnostic agents, Biotechnology, Microbiology, Catalysis, others (pigment related systems -colorants, cosmetics, inks, coatings semiconductor technology, optics, foods, pesticides, flame retardants)
Property enhancement, Reduced material costsIntellectual property coverage/web sites/ publications
Improved performance, Reduced cost of use
Simplified production, Improved yield
Examples of nano-dispersed and sub-micron solid particle systems
Leveraging Size-reduction technology/ technology transferFormulary considerations, Process ConsiderationsCriteria for preparing fine solid-particle dispersions via size reduction
Process Scaleability
Solubility of dispersed phase in liquid mediumDevelopment of VALUE-ADDED dispersed systems (experimental)
Stability of dispersed phases (physical, chemical, morphological)
Friability, Size of dispersed phase
Consistency of dispersed phase
Define medium for dispersed phaseDemonstrate small-scale manufacturability and full scale manufacturability
Define customers objectives
Identify characterization and analytical methods for dispersed systems and starting materials
Understand the effects of particle size and
distribution on product response
Demonstrate technical feasibility for such processing
Instructor
John Bishop has over thirty years of industrial experience in fine
particle and coating technologies. He received his chemical engineering
degree from Villanova University and has been employed by Eastman Kodak
Company. He is an experienced particle dispersion technologist, and
an enthusiastic lecturer and technology-transfer agent. He has developed,
scaled-up and commercialized solid dispersed systems for a broad range of
applications including pharmaceuticals, ink-jet imaging, diagnostic health
sciences and others high-value markets. He is an inventor and author
of twenty-four patents and several technical articles. He has received
awards including induction into Kodak’s Distinguished Inventors’ Gallery
and several innovation awards for novel technical accomplishments. He recently
has been consulting in the Pacific Rim. He is a strong proponent of the adage”
it pays to think small”.
(C) 2004 Particles Conference