Size-Reduction Dispersion Technology




Synopsis:

The formation of solid-dispersed particle systems as fine as 10 nanometers via comminution is a multi-discipline technology that can create or extend functionality to a broad range of materials.  Learn that “it pays to think small” and develop an understanding for this commercializable technology.  Size reduction technology is applicable in many unrelated areas including pharmaceuticals, biotechnology, microbiology, diagnostic agents, and other advanced solid materials. This course will provide the attendee with an understanding of the characteristics, opportunities and benefits of ultrafine solid particle dispersed systems using comminution size reduction dispersion technology.

Who Should Attend:

R&D managers , engineers, scientists and bio-technologists interested in the value-added consequences and benefits of forming ultrafine particle-based systems of functional materials are encouraged to attend.  The course is primarily targetted at the B.S. level, but graduate and postgradaute level students seeking an introductory overview of this processing technology will also greatly benefit from the course.

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Topics Covered:

Size-Reduction Dispersion Technology

* Introduction
       Ground rules
        Interactive (Q&A encouraged and welcome)
        Overview of schedule, presentation, breaks, discussion

* Comminution Technology
           Technology and miniaturization- think tiny
            Vision (Richard Smalley)
            Why miniaturization-faster/smaller/cheaper
            Particle Building Blocks (diagram)
            Dispersions and coatings
            High surface area materials
            Consolidated materials and parts
* What is Fine Particle Technology ???
           Formation of Solid Particles - comminution technology
            Types of dispersed systems (solid/gas, solid/liquid, solid/solid.)
            Conventional Size Reduction Capabilities (sub-micron systems)
                and Bead milling technology
            Micro-milling and capabilities (nanoparticle formation)
* Applications for this technology
            Pharmaceuticals, Implant Technology,
             Biotechnology,  Diagnostic Agents,
             Microbiology, Cosmeceuticals,
             Neutriceuticals, others
             (Information storage, inks, electronics
             mineral processing, office products
             agricultural products)
* Characteristics of sub-micron and nanoparticle
  solid-dispersed systems
            Established technology, Excellent
                dispersion stability
             Property amplification, Reliable analytical methods
             Comparison of size reduction methods
             Processing speed and output, Dispersion purity
             Cost, Process scalability, Skill level, Process flexibility
             Solids content, Capital expense, Extent of size reduction
* Comparison of sub-micron and nanoparticle
     systems:
           Size, surface area, number of particle per unit weight
            Purity, Micrographs
* What are limits of size-reduction and bead
     milling technology?
           Size, surface area expectations (10 X better than sub-micron)
* What are characteristics of fine particles that
    make for commercial utility?
            Solubility amplification, Surface area sensitive properties
            Incorporation technology for high value materials
            Incorporation of insoluble materials
            Elimination of hazardous organic solvents
            Physics of light scattering (more spectrally selective pigments)
* How compelling are potential applications for – ultrafine particles and size reduction technology?
* Where are opportunities for ultrafine solid systems and size reduction technology ?
            Drug Delivery, Neutriceuticals, Cosmeceuticals,
                Advanced materials, Diagnostic agents, Biotechnology,
                Microbiology, Catalysis, others
                    (pigment related systems -colorants, cosmetics,
                    inks, coatings semiconductor technology, optics,
                   foods, pesticides, flame retardants)
* Commercial benefits of ultrafine particle systems:
           Property enhancement, Reduced material costs
            Improved performance, Reduced cost of use
            Simplified production, Improved yield
* Intellectual property coverage/web sites/ publications
* Examples of nano-dispersed and sub-micron solid particle systems
* Leveraging Size-reduction technology/ technology transfer
           Formulary considerations, Process Considerations
            Process Scaleability
* Criteria for preparing fine solid-particle dispersions via size reduction
           Solubility of dispersed phase in liquid medium
            Stability of dispersed phases (physical, chemical,
                morphological)
            Friability, Size of dispersed phase
            Consistency of dispersed phase
* Development of VALUE-ADDED dispersed systems (experimental)
           Define medium for dispersed phase
            Define customers objectives
            Identify characterization and analytical methods for
                dispersed systems and starting materials
            Understand the effects of particle size and distribution
                on product response
            Demonstrate technical feasibility for such processing
* Demonstrate small-scale manufacturability and full scale manufacturability
 
 
 

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Instructor

John Bishop has over thirty years of industrial experience in fine particle and coating technologies.  He received his chemical engineering degree from Villanova University and  has been employed by Eastman Kodak Company.  He is an experienced particle dispersion technologist, and an enthusiastic lecturer and technology-transfer agent.  He has developed, scaled-up and commercialized solid dispersed systems for a broad range of applications including pharmaceuticals, ink-jet imaging, diagnostic health sciences and others high-value markets.  He is an inventor and author of twenty-four patents and several technical articles.  He has received awards including induction into Kodak’s Distinguished Inventors’ Gallery and several innovation awards for novel technical accomplishments. He recently has been consulting in the Pacific Rim. He is a strong proponent of the adage” it pays to think small”.
 

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(C)  2002,2003  Particles Conference