The formation of solid-dispersed particle systems as fine as 10 nanometers via comminution is a multi-discipline technology that can create or extend functionality to a broad range of materials. Learn that “it pays to think small” and develop an understanding for this commercializable technology. Size reduction technology is applicable in many unrelated areas including pharmaceuticals, biotechnology, microbiology, diagnostic agents, and other advanced solid materials. This course will provide the attendee with an understanding of the characteristics, opportunities and benefits of ultrafine solid particle dispersed systems using size reduction dispersion technology.
Who Should Attend:
R&D managers , engineers, scientists and bio-technologists interested in the value-added consequences and benefits of forming ultrafine particle-based systems of functional materials are encouraged to attend.
* Comminution Technology
Technology and miniaturization- think tiny
Vision (Richard Smalley)
Why miniaturization-faster/smaller/cheaper
Particle Building Blocks (diagram)
Dispersions and coatings
High surface area materials
Consolidated materials and parts
* What is Fine Particle Technology
???
Formation of Solid Particles - comminution
technology
Types of dispersed systems (solid/gas, solid/liquid, solid/solid.)
Conventional Size Reduction Capabilities (sub-micron systems)
and Bead milling technology
Micro-milling and capabilities (nanoparticle formation)
* Applications for this technology
Pharmaceuticals, Implant Technology,
Biotechnology, Diagnostic Agents,
Microbiology, Cosmeceuticals,
Neutriceuticals, others
(Information storage, inks, electronics
mineral processing, office products
agricultural products)
* Characteristics of sub-micron
and nanoparticle
solid-dispersed systems
Established technology, Excellent
dispersion stability
Property amplification, Reliable analytical methods
Comparison of size reduction methods
Processing speed and output, Dispersion purity
Cost, Process scalability, Skill level, Process flexibility
Solids content, Capital expense, Extent of size reduction
* Comparison of sub-micron and
nanoparticle
systems:
Size, surface area, number of particle per
unit weight
Purity, Micrographs
* What are limits of size-reduction
and bead
milling
technology?
Size, surface area expectations (10 X better
than sub-micron)
* What are characteristics of
fine particles that
make for
commercial utility?
Solubility amplification, Surface area sensitive properties
Incorporation technology for high value materials
Incorporation of insoluble materials
Elimination of hazardous organic solvents
Physics of light scattering (more spectrally selective pigments)
* How compelling are potential
applications for – ultrafine particles and size reduction technology?
* Where are opportunities for
ultrafine solid systems and size reduction technology ?
Drug Delivery, Neutriceuticals, Cosmeceuticals,
Advanced materials, Diagnostic agents, Biotechnology,
Microbiology, Catalysis, others
(pigment related systems -colorants, cosmetics,
inks, coatings semiconductor technology, optics,
foods, pesticides, flame retardants)
* Commercial benefits of ultrafine
particle systems:
Property enhancement, Reduced material costs
Improved performance, Reduced cost of use
Simplified production, Improved yield
* Intellectual property coverage/web
sites/ publications
* Examples of nano-dispersed
and sub-micron solid particle systems
* Leveraging Size-reduction
technology/ technology transfer
Formulary considerations, Process Considerations
Process Scaleability
* Criteria for preparing fine
solid-particle dispersions via size reduction
Solubility of dispersed phase in liquid medium
Stability of dispersed phases (physical, chemical,
morphological)
Friability, Size of dispersed phase
Consistency of dispersed phase
* Development of VALUE-ADDED
dispersed systems (experimental)
Define medium for dispersed phase
Define customers objectives
Identify characterization and analytical methods for
dispersed systems and starting materials
Understand the effects of particle size and distribution
on product response
Demonstrate technical feasibility for such processing
* Demonstrate small-scale manufacturability
and full scale manufacturability
Instructor
John Bishop has over thirty years of industrial experience in fine
particle and coating technologies. He received his chemical engineering
degree from Villanova University and has been employed by Eastman
Kodak Company. He is an experienced particle dispersion technologist,
and an enthusiastic lecturer and technology-transfer agent. He has
developed, scaled-up and commercialized solid dispersed systems for a broad
range of applications including pharmaceuticals, ink-jet imaging, diagnostic
health sciences and others high-value markets. He is an inventor
and author of twenty-four patents and several technical articles.
He has received awards including induction into Kodak’s Distinguished Inventors’
Gallery and several innovation awards for novel technical accomplishments.
He recently has been consulting in the Pacific Rim. He is a strong proponent
of the adage” it pays to think small”.
(C) 2002 Particles
Conference